hiPSC Disease Modeling

Starting points for model generation

• Biopsy material (e.g. skin, blood) from clinically diagnosed individuals for the generation of hiPSCs and derived cell types

  • Benefit from a patient's genetic background

  • Identify and validate disease-causing or - modulating targets and associated mechanisms

• Generation of synthetic disease models and isogenic lines based on well characterized healthy donor lines by CRISPR/Cas9 genome editing
  • Build your custom and barcoded disease model
  • Test your drug candidates/lead compounds in human in vitro models with increased predictivity

Phenotypic analyses of hiPSC-derived disease models

• Benefit from a wide range of robust differentiation protocols (using forced expression of transcription factors or the application of small molecules/growth factors/morphogens)

• Choose from 2D and/or 3D differentiation strategies and models

• Apply a diverse set of image-/microscopy-based, plate-reader assisted or protemoics approaches for in-depth description, characterization and analysis of your model

• Gain valuable insights into gene expression alterations and models' cellular composition via single cell Sequencing (scSeq; in cooperation with CeGaT GmbH)