Our Products: Modified Luminex Beads
As a Luminex® partner, we offer ready-to-use modified MagPlex® microspheres for Luminex® assays. These can be used for protein studies for a variety of applications:
- High-throughput screening of antibodies and antigens
- Serology assays
- Biomarker assays
- Protein-protein interaction studies
Immunoassays are our expertise
NMI TT Pharmaservices has a long-standing track record in immuno-assays and immobilization strategies using several alternative surface chemistries (e.g. amine, maleimide or hydrazide chemistry). Also, we have accumulated specialist expertise in the development of high-quality Luminex® immuno-assays for different analytes.
High quality and reproducibility
Our coupling process in 96-well format, together with rigid quality control, ensure that we provide our customers with products of the highest quality and reproducibility.
As a standard, we ship 10 million beads per 1 mL, for one bead identity in a set of at least four bead identities. However, custom formulations are available upon request.
Streptavidin and neutravidin beads
MagPlex® beads coated with avidin (streptavidin or neutravidin) can be used for immobilization of biotinylated proteins, antibodies or peptides. As our modified MagPlex® microspheres are compatible with all Luminex® xMAP instruments, they can be used for a multitude of biological assays. For example, our neutravidin microspheres are the basis of our multiplex protein profiling technology DigiWest.
Custom bead coupling services
We also offer tailored coupling of MagPlex® beads according to your needs, with your desired bead identities or capture reagents, and functionalized with your own antibodies, proteins or peptides. All our modified microsphere products are quality-tested for their coupling and delivered ready-to-use for your Luminex® assays.
References
- Nonyane, Bareng AS, et al. "Serologic responses in childhood pulmonary tuberculosis." The Pediatric infectious disease journal 37.1 (2018): 1.
- Filomena, Angela, et al. "Performance of a multiplex serological Helicobacter pylori assay on a novel microfluidic assay platform." Proteomes 5.4 (2017): 24.
- Bohm, Katrin, et al. "Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology." Vaccine 35.43 (2017): 5883-5889.
- Broger, Tobias, et al. "Diagnostic performance of tuberculosis-specific IgG antibody profiles in patients with presumptive tuberculosis from two continents." Clinical Infectious Diseases 64.7 (2017): 947-955.
- Filomena, Angela, et al. "Study of the Humoral Immune Response towards HCV Genotype 4 Using a Bead-Based Multiplex Serological Assay." High-throughput 6.4 (2017): 15.
- Filomena, Angela, et al. "Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori." High-throughput 6.4 (2017): 14.
- Brockmann, Kathrin, et al. "Inflammatory profile in LRRK2-associated prodromal and clinical PD." Journal of neuroinflammation 13.1 (2016): 122.
- Milewski, Morlin C., et al. "A standardized production pipeline for high profile targets from Mycobacterium tuberculosis." PROTEOMICS–Clinical Applications 10.9-10 (2016): 1049-1057.
- Planatscher, Hannes, et al. "Systematic reference sample generation for multiplexed serological assays." Scientific reports 3.1 (2013): 1-5.