Through extensive analysis of a growing number of patient-derived microtumours (PDMs) from diverse cancer types - together with autologous TILs and PBMCs - we have established an advanced, versatile service platform for immuno-oncology (IO) testing of drug candidates, immunotherapies, and combination treatments.
PDM in Ovarian Cancer: Anderle N, et. al. Platform of Patient-Derived Microtumors Identifies Individual Treatment Responses and Therapeutic Vulnerabilities in Ovarian Cancer. Cancer (Basel) 2022
Potential of renal cell carcinoma PDMs and TILs for treatment response prediction: Erne E, et. al. Patient-derived microtumors: Potential for therapeutic response prediction-a case study. Urologie 2022
PDMs used for efficacy testing of novel combination treatment approaches in neurooncology:
Przystal J M, et. al. Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma. Cancers (Basel) 2021
Walter B, et. al. Argyrin F Treatment-Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma. Advanced Therapeutics 2021